Structure of PDB 4fbw Chain B Binding Site BS02

Receptor Information

>4fbw Chain B (length=386) Species: 284812 (Schizosaccharomyces pombe 972h-)

NENTIRILISSDPHVGYGEKDPVRGNDSFVSFNEILEIARERDVDMILLG
GDIFHDNKPSRKALYQALRSLRLNCLGDKPCELELLSDAVCNINYLDPNI
NVAIPVFSIHGNHDDRYSALDILQVTGLVNYFGRVPENDNIVVSPILLQK
GFTKLALYGISNVRDERLYHSFRENKVKFLRPDLYRDEWFNLLTVHQNHS
AHTPTSYLPESFIQDFYDFVLWGHEHECLIDGSYNPTQKFTVVQPGSTIA
TSLSPGETAPKHCGILNITGKDFHLEKIRLRTVRPFIMKDIILSEVSSIP
PMVENKKEVLTYLISKVEEAITEANAQWYEAQGTVPVVENEKPPLPLIRL
RVDYTGGYQTENPQRFSNRFVGRVANATDVVQFYLK

Ligand information

>4fbw Chain D (length=16) Species: 284812 (Schizosaccharomyces pombe 972h-)

EENRRLRNLGSVEYIR

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4fbw Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): Y195 F198 R199 N201 V203 K204 F205 L206 R207 D209 R212 Y233 S237 F238 Q240 D241 T263
• Binding residue (residue number reindexed from 1): Y169 F172 R173 N175 V177 K178 F179 L180 R181 D183 R186 Y207 S211 F212 Q214 D215 T237

Enzymatic activity

• Enzyme Commision number: 3.1.-.-

Gene Ontology

Molecular Function

• GO:0004519 endonuclease activity
• GO:0004520 DNA endonuclease activity
• GO:0008296 3'-5'-DNA exonuclease activity
• GO:0016787 hydrolase activity
• GO:0030145 manganese ion binding

Biological Process

• GO:0006302 double-strand break repair

Cellular Component

• GO:0005634 nucleus
• GO:0030870 Mre11 complex

External links

• PDB: RCSB:4fbw, PDBe:4fbw, PDBj:4fbw
• PDBsum: 4fbw
• PubMed: 22705791
• UniProt: Q09683|RAD32_SCHPO Double-strand break repair protein rad32 (Gene Name=rad32)