Structure of PDB 4f5d Chain B Binding Site BS02

Receptor Information
>4f5d Chain B (length=188) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
FNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILL
PLDCGVPDNLSMADPNIRFLDKLPQQTADRAGIKDRVYSNSIYELLENGQ
RAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADA
PESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEE
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain4f5d Chain B Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4f5d The structural basis for the sensing and binding of cyclic di-GMP by STING
Resolution3.0 Å
Binding residue
(original residue number in PDB)		G166 R232 R238
Binding residue
(residue number reindexed from 1)		G14 R80 R86
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0002218 activation of innate immune response
GO:0032481 positive regulation of type I interferon production

View graph for
Biological Process
External links
PDB RCSB:4f5d, PDBe:4f5d, PDBj:4f5d
PDBsum4f5d
PubMed22728659
UniProtQ86WV6|STING_HUMAN Stimulator of interferon genes protein (Gene Name=STING1)

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