Structure of PDB 4eyh Chain B Binding Site BS02

Receptor Information
>4eyh Chain B (length=377) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGV
KKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGF
DENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLV
GSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPES
CQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGI
SVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELL
ASLLNRVCQDGRKPHTVRLIIRRGRESRQCPIPSHVIQKYDVMTPMVDIL
MKLFRNMVNVKMPFHLTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
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PDB4eyh Replication of a carcinogenic nitropyrene DNA lesion by human Y-family DNA polymerase.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		L123 E127 K207 P240 G241 G243 K245 T246 E358 S359 R360 Q361
Binding residue
(residue number reindexed from 1)		L98 E102 K182 P215 G216 G218 K220 T221 E326 S327 R328 Q329
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4eyh, PDBe:4eyh, PDBj:4eyh
PDBsum4eyh
PubMed23268450
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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