Structure of PDB 4da4 Chain B Binding Site BS02

Receptor Information
>4da4 Chain B (length=832) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DRISWLGQPMKIEENRTYYQKVSIDEEMLEVGDCVSVIPDDSSKPLYLAR
VTALWEDKNGQMMFHAHWFCAGTDTVLGATSDPLELFLVGECENMQLSYI
HSKVKVIYKAPSENWAMEGGGKTYFFQLWYNQEYARFESPPKTQPTEDNK
HKFCLSCIRLAELRQKEMPKVLEQIEEVDGRVYCSSITKNGVVYRLGDSV
YLPPEAFTFNIKVASPVKRPKKDPVNETLYPEHYRKYSDYIKGSNLDAPE
PYRIGRIKEIHCGKKKGKVNEADIKLRLYKFYRPENTHRSYNGSYHTDIN
MLYWSDEEAVVNFSDVQGRCTVEYGEDLLESIQDYSQGGPDRFYFLEAYN
SKTKNFEDPPNHARSPGNIKLPKLRTLDVFSGCGGLSEGFHQAGISETLW
AIEMWDPAAQAFRLNNPGTTVFTEDCNVLLKLVMAGEVTNSLGQRLPQKG
DVEMLCGGPPCQGFSGMNRFNSRTYSKFKNSLVVSFLSYCDYYRPRFFLL
ENVRNFVSYRRSMVLKLTLRCLVRMGYQCTFGVLQAGQYGVAQTRRRAII
LAAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRTI
TVRDTMSDLPEIQNGASNSEIPYNGEPLSWFQRQLRGSHYQPILRDHICK
DMSPLVAARMRHIPLFPGSDWRDLPNIQVRLGDGVIAHKLQYTFHDVKNG
YSSTGALRGVCSCAEGKACDPESRQFSTLIPWCLPHTGNRHNHWAGLYGR
LEWDGFFSTTVTNPEPMGKQGRVLHPEQHRVVSVRECARSQGFPDSYRFF
GNILDRHRQVGNAVPPPLAKAIGLEIKLCLLS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4da4 Structure-Based Mechanistic Insights into DNMT1-Mediated Maintenance DNA Methylation.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		S981 Y983 K985 P1227 P1228 C1229 Q1230 S1233 M1235 N1236 F1238 Y1243 E1269 V1271 R1314 R1315 T1527 T1530 G1536 K1537 N1580
Binding residue
(residue number reindexed from 1)		S238 Y240 K242 P459 P460 C461 Q462 S465 M467 N468 F470 Y475 E501 V503 R546 R547 T759 T762 G768 K769 N812
Enzymatic activity
Catalytic site (original residue number in PDB) C1229 E1269 R1313 R1315
Catalytic site (residue number reindexed from 1) C461 E501 R545 R547
Enzyme Commision number 2.1.1.37: DNA (cytosine-5-)-methyltransferase.
Gene Ontology
Molecular Function
GO:0003682 chromatin binding
GO:0008168 methyltransferase activity

View graph for
Molecular Function
External links
PDB RCSB:4da4, PDBe:4da4, PDBj:4da4
PDBsum4da4
PubMed22323818
UniProtP13864|DNMT1_MOUSE DNA (cytosine-5)-methyltransferase 1 (Gene Name=Dnmt1)

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