Structure of PDB 4cog Chain B Binding Site BS02

Receptor Information

>4cog Chain B (length=207) Species: 216591 (Burkholderia cenocepacia J2315) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TLWDISPPVSPATPVWPGDTPVAVERVWRMEAGSPVNVARLTLSPHTGAH
CDAPLHYDADGAPIGAVPLDTYLGPCRVIHCIGAAPVVRPADVEAALDGV
PPRVLLRTYARAAVEQWDSNFCAVAPDTVDLLAAHGVKLIGIDTPSLDPQ
ESKTMDAHRRVRAHRMAILEGIVLDDVPPGDYELIALPLKFATLDASPVR
AVLRALP

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

4cog Chain B Residue 1210 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4cog Structure of Bacterial Kynurenine Formamidase Reveals a Crowded Binuclear-Zinc Catalytic Site Primed to Generate a Potent Nucleophile.
Resolution	1.6 Å
Binding residue (original residue number in PDB)	D60 D62
Binding residue (residue number reindexed from 1)	D58 D60
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.5.1.9: arylformamidase.

Gene Ontology

	Molecular Function
GO:0004061	arylformamidase activity
GO:0004328	formamidase activity
GO:0008270	zinc ion binding
GO:0016787	hydrolase activity
GO:0046872	metal ion binding

	Biological Process
GO:0006569	tryptophan catabolic process
GO:0019441	tryptophan catabolic process to kynurenine
GO:0043420	anthranilate metabolic process

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Molecular Function

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Biological Process

External links

PDB	RCSB:4cog, PDBe:4cog, PDBj:4cog
PDBsum	4cog
PubMed	24942958
UniProt	B4E9I9\|KYNB_BURCJ Kynurenine formamidase (Gene Name=kynB)

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