Structure of PDB 4cn5 Chain B Binding Site BS02

Receptor Information
>4cn5 Chain B (length=75) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCKDCLIDKRQR
NRCQYCRYQKCLAMGMKREAVQEER
Ligand information
Receptor-Ligand Complex Structure
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PDB4cn5 Structural Basis of Natural Promoter Recognition by the Retinoid X Nuclear Receptor.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		E153 G154 R161 R184 N185 Q188 R191
Binding residue
(residue number reindexed from 1)		E22 G23 R30 R50 N51 Q54 R57
Binding affinityPDBbind-CN: Kd=40nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003700 DNA-binding transcription factor activity
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:4cn5, PDBe:4cn5, PDBj:4cn5
PDBsum4cn5
PubMed25645674
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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