Structure of PDB 4cc9 Chain B Binding Site BS02

Receptor Information
>4cc9 Chain B (length=98) Species: 11723 (Simian immunodeficiency virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RERIPPGNSGEETIGEAFDWLDRTVEEINRAAVNHLPRELIFQVWRRSWE
YWHDEMGMSVSYTKYRYLCLIQKAMFMHCKKGCRCLRPGPPPPPPPGL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4cc9 Chain B Residue 1112 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB4cc9 Structural Basis of Lentiviral Subversion of a Cellular Protein Degradation Pathway.
Resolution2.473 Å
Binding residue
(original residue number in PDB)		H39 H82 C87 C89
Binding residue
(residue number reindexed from 1)		H35 H78 C83 C85
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0019049 virus-mediated perturbation of host defense response
GO:0019058 viral life cycle
GO:0052170 symbiont-mediated suppression of host innate immune response
Cellular Component
GO:0042025 host cell nucleus
GO:0044423 virion component

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4cc9, PDBe:4cc9, PDBj:4cc9
PDBsum4cc9
PubMed24336198
UniProtP19508|VPX_SIVSP Protein Vpx (Gene Name=vpx)

[Back to BioLiP]