Structure of PDB 4c2d Chain B Binding Site BS02

Receptor Information

>4c2d Chain B (length=433) Species: 224308 (Bacillus subtilis subsp. subtilis str. 168)

SERDKAMDKIEKAYELISNEYVEKVDREKLLEGAIQGMLSTLNDPYSVYM
DKQTAKQFSDSLDSSFEGIGAEVGMEDGKIIIVSPFKKSPAEKAGLKPND
EIISINGESMAGKDLNHAVLKIRGKKGSSVSMKIQRPGTKKQLSFRIKRA
EIPLETVFASEKKVQGHSVGYIAISTFSEHTAEDFAKALRELEKKEIEGL
VIDVRGNPGGYLQSVEEILKHFVTKDQPYIQIAERNGDKKRYFSTLTHKK
AYPVNVITDKGSASASEILAGALKEAGHYDVVGDTSFGKGTVQQAVPMGD
GSNIKLTLYKWLTPNGNWIHKKGIEPTIAIKQPDYFSAGPLQLKEPLKVD
MNNEDVKHAQVLLKGLSFDPGREDGYFSKDMKKAVMAFQDQNKLNKTGVI
DTRTAETLNQQIEKKKSDEKNDLQLQTALKSLF

Ligand information

>4c2d Chain N (length=4) Species: 511693 (Escherichia coli BL21)

PQTA

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4c2d Ctpb Assembles a Gated Protease Tunnel Regulating Cell-Cell Signaling During Spore Formation in Bacillus Subtilis.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): Q102 F111 G113 I114 G115 A116 V118 L160 N161 I167 R168
• Binding residue (residue number reindexed from 1): Q57 F66 G68 I69 G70 A71 V73 L115 N116 I122 R123

Enzymatic activity

• Enzyme Commision number: 3.4.21.102: C-terminal processing peptidase.

Gene Ontology

Molecular Function

• GO:0004175 endopeptidase activity
• GO:0004252 serine-type endopeptidase activity
• GO:0005515 protein binding
• GO:0008233 peptidase activity
• GO:0008236 serine-type peptidase activity
• GO:0042277 peptide binding
• GO:0042802 identical protein binding
• GO:0042803 protein homodimerization activity

Biological Process

• GO:0006508 proteolysis
• GO:0006518 peptide metabolic process
• GO:0007165 signal transduction
• GO:0030435 sporulation resulting in formation of a cellular spore

Cellular Component

• GO:0030288 outer membrane-bounded periplasmic space

External links

• PDB: RCSB:4c2d, PDBe:4c2d, PDBj:4c2d
• PDBsum: 4c2d
• PubMed: 24243021
• UniProt: O35002|CTPB_BACSU Carboxy-terminal processing protease CtpB (Gene Name=ctpB)