Structure of PDB 4c1k Chain B Binding Site BS02

Receptor Information

>4c1k Chain B (length=262) Species: 2261 (Pyrococcus furiosus)

MKYSKEYKEKTVVKINDVKFGEGFTIIAGPCSIESRDQIMKVAEFLAEVG
IKVLRGGAFKPRTSPYSFQGYGEKALRWMREAADEYGLVTVTEVMDTRHV
ELVAKYSDILQIGARNSQNFELLKEVGKVENPVLLKRGMGNTIQELLYSA
EYIMAQGNENVILCERGIRTFETATRFTLDISAVPVVKELSHLPIIVDPS
HPAGRRSLVIPLAKAAYAIGADGIMVEVHPEPEKALSDSQQQLTFDDFLQ
LLKELEALGWKG

Ligand information

• Ligand ID: CO3
• InChI: InChI=1S/CH2O3/c2-1(3)4/h(H2,2,3,4)/p-2
• InChIKey: BVKZGUZCCUSVTD-UHFFFAOYSA-L
• SMILES:
  OpenEye OEToolkits 1.5.0: C(=O)([O-])[O-]
  ACDLabs 10.04
  CACTVS 3.341: [O-]C([O-])=O
• Formula: C O3
• Name: CARBONATE ION
• DrugBank: DB14531
• PDB chain: 4c1k Chain B Residue 1265

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4c1k Destabilization of the Homotetrameric Assembly of 3-Deoxy-D-Arabino-Heptulosonate 7-Phosphate Synthase from the Hyperthermophile Pyrococcus Furiosus Enhances Enzymatic Activity
• Resolution: 2.15 Å
• Binding residue (original residue number in PDB): G113 A114 K136 R166
• Binding residue (residue number reindexed from 1): G113 A114 K136 R166
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.5.1.54: 3-deoxy-7-phosphoheptulonate synthase.

Gene Ontology

Molecular Function

• GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity
• GO:0016740 transferase activity
• GO:0016832 aldehyde-lyase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0009058 biosynthetic process
• GO:0009073 aromatic amino acid family biosynthetic process

External links

• PDB: RCSB:4c1k, PDBe:4c1k, PDBj:4c1k
• PDBsum: 4c1k
• PubMed: 24239948
• UniProt: Q8U0A9