Structure of PDB 4bxf Chain B Binding Site BS02

Receptor Information
>4bxf Chain B (length=422) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SALNFDSPSSLFESLISPIKTETFFKEFWEQKPLLIQRDDPALATYYGSL
FKLTDLKSLCSRGMYYGRDVNVCRCVNGKKKVLNKDGKAHFLQLRKDFDQ
KRATIQFHQPQRFKDELWRIQEKLECYFGSLVGSNVYITPAGSQGLPPHY
DDVEVFILQLEGEKHWRLYHPTVPLARECSVEAEERIGRPVHEFMLKPGD
LLYFPRGTIHQADTPAGLAHSTHVTISTYQNNSWGDFLLDTISGLVFDTA
KEDVELRTGIPRQLLLQVESTTVATRRLSGFLRTLADRLEGTKELLSSDM
KKDFIMHRLPPYSAGDGAELSTPGGKLPRLDSVVRLQFKDHIVLTVLPQE
KMVYIYHSLKNSRETHMMTEFHGLRFPLSHLDALKQIWNSPAISVKDLKL
TTDEEKESLVLSLWTECLIQVV
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain4bxf Chain B Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4bxf Ribosomal oxygenases are structurally conserved from prokaryotes to humans.
Resolution2.05 Å
Binding residue
(original residue number in PDB)		H179 D181 H240
Binding residue
(residue number reindexed from 1)		H149 D151 H210
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.11.79: protein-L-histidine (3S)-3-hydroxylase.
Gene Ontology
Molecular Function
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0032452 histone demethylase activity
GO:0032453 histone H3K4 demethylase activity
GO:0036139 peptidyl-histidine dioxygenase activity
GO:0042802 identical protein binding
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
GO:0051864 histone H3K36 demethylase activity
Biological Process
GO:0006338 chromatin remodeling
GO:0042254 ribosome biogenesis
GO:0045892 negative regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription regulator complex
GO:0005730 nucleolus
GO:0005829 cytosol

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:4bxf, PDBe:4bxf, PDBj:4bxf
PDBsum4bxf
PubMed24814345
UniProtQ8IUF8|RIOX2_HUMAN Ribosomal oxygenase 2 (Gene Name=RIOX2)

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