Structure of PDB 4buo Chain B Binding Site BS02

Receptor Information
>4buo Chain B (length=314) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGPNSDLDVNTDIYSKVLVTAIYLALFVVGTVGNSVTLFTLARLQSTVDY
YLGSLALSDLLILLLAMPVELYNFIWVHHPWAFGDAGCRGYYFLRDACTY
ATALNVVSLSVELYLAICHPFKAKTLMSRSRTKKFISAIWLASALLAIPM
LFTMGLQNLSGDGTHPGGLVCTPIVDTATLKVVIQVNTFMSFLFPMLVAS
ILNTVIANKLTVMVHQAAFNMTIEPGRVQALRRGVLVLRAVVIAFVVCWL
PYHVRRLMFCYISDEQWTTFLFDFYHYFYMLTNALVYVSAAINPILYNLV
SANFRQVFLSTLAC
Ligand information
Ligand IDGLY
InChIInChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKeyDHMQDGOQFOQNFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C(=O)O)N
CACTVS 3.341NCC(O)=O
ACDLabs 10.04O=C(O)CN
FormulaC2 H5 N O2
NameGLYCINE
ChEMBLCHEMBL773
DrugBankDB00145
ZINCZINC000004658552
PDB chain4buo Chain B Residue 1388 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4buo Structure of Signaling-Competent Neurotensin Receptor 1 Obtained by Directed Evolution in Escherichia Coli
Resolution2.75 Å
Binding residue
(original residue number in PDB)		Q99 R305 S373 N375
Binding residue
(residue number reindexed from 1)		Q45 R233 S301 N303
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0004930 G protein-coupled receptor activity
GO:0016492 G protein-coupled neurotensin receptor activity
Biological Process
GO:0007186 G protein-coupled receptor signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4buo, PDBe:4buo, PDBj:4buo
PDBsum4buo
PubMed24453215
UniProtP20789|NTR1_RAT Neurotensin receptor type 1 (Gene Name=Ntsr1)

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