Structure of PDB 4ba2 Chain B Binding Site BS02

Receptor Information

>4ba2 Chain B (length=234) Species: 2287 (Saccharolobus solfataricus)

ERPKLILDDGKRTDGRKPDELRSIKIELGVLKNADGSAIFEMGNTKAIAA
VYGPKEMHPRHLSLPDRAVLRVRYHMTPFSTDERKNPAPSRREIELSKVI
REALESAVLVELFPRTAIDVFTEILQADAGSRLVSLMAASLALADAGIPM
RDLIAGVAVGKADGVIILDLNETEAMWGEADMPIAMMPSLNQVTLFQLNG
SMTPDEFRQAFDLAVKGINIIYNLEREALKSKYV

Ligand information

• Ligand ID: PO4
• InChI: InChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
• InChIKey: NBIIXXVUZAFLBC-UHFFFAOYSA-K
• SMILES:
  CACTVS 3.341: [O-][P]([O-])([O-])=O
  ACDLabs 10.04: [O-]P([O-])([O-])=O
  OpenEye OEToolkits 1.5.0: [O-]P(=O)([O-])[O-]
• Formula: O4 P
• Name: PHOSPHATE ION
• DrugBank: DB14523
• PDB chain: 4ba2 Chain B Residue 1242

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4ba2 Crystal Structure of a 9-Subunit Archaeal Exosome in Pre-Catalytic States of the Phosphorolytic Reaction.
• Resolution: 2.501 Å
• Binding residue (original residue number in PDB): R99 A136 G137 S138 R139
• Binding residue (residue number reindexed from 1): R92 A129 G130 S131 R132
• Annotation score: 3

Enzymatic activity

• Enzyme Commision number: 3.1.13.-

Gene Ontology

Molecular Function

• GO:0000175 3'-5'-RNA exonuclease activity
• GO:0003723 RNA binding
• GO:0004527 exonuclease activity
• GO:0005515 protein binding
• GO:0016896 RNA exonuclease activity, producing 5'-phosphomonoesters

Biological Process

• GO:0006401 RNA catabolic process
• GO:0016075 rRNA catabolic process

Cellular Component

• GO:0000177 cytoplasmic exosome (RNase complex)
• GO:0000178 exosome (RNase complex)
• GO:0005737 cytoplasm

External links

• PDB: RCSB:4ba2, PDBe:4ba2, PDBj:4ba2
• PDBsum: 4ba2
• PubMed: 23319881
• UniProt: Q9UXC2|RRP41_SACS2 Exosome complex component Rrp41 (Gene Name=rrp41)