Structure of PDB 4ar8 Chain B Binding Site BS02

Receptor Information
>4ar8 Chain B (length=389) Species: 1513 (Clostridium tetani) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NKLIEEGKKHYLPKTYTFDNGKIIIKAGDKVEESKIQKLYWASKEVKSQF
HRIIGNDKPLEVGNADDILTIVIYNNPEEYKLNKTLYGYSVDNGGIYIEG
IGTFFTYERTPQESIYSLEELFRHEFTHYLQGRYLIPGLFNKGDFYKGNN
GRITWFEEGSAEFFAGSTRTSVLPRKSMVGGLSKNPKERFNADKLLHSKY
SDGWDFYKYGYAFSDYMYNNNKKLFSDLVSTMKNNDVKGYEALIEESSKD
SKINKDYEYHMENLVNNYDNYTIPLVSDDYMKQYDNKSLHEIKSDIEKAM
DVKNSQITKESSQYFDTYNLKATYTLSSNKGEISNWNYMNNKINEALNKL
DNLSWGGYKTVTAYFSNPRLNSNNEVVYDIVFHGLLSHN
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4ar8 Chain B Residue 1731 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4ar8 Structural Basis for Activity Regulation and Substrate Preference of Clostridial Collagenases G, H, and T.
Resolution2.05 Å
Binding residue
(original residue number in PDB)		H465 H469 E499
Binding residue
(residue number reindexed from 1)		H124 H128 E158
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.3: microbial collagenase.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4ar8, PDBe:4ar8, PDBj:4ar8
PDBsum4ar8
PubMed23703618
UniProtQ899Y1|COLT_CLOTE Collagenase ColT (Gene Name=colT)

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