Structure of PDB 4a09 Chain B Binding Site BS02

Receptor Information

>4a09 Chain B (length=354) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

QTSILHYIYKSSLGQSIHAQLRQCLQEPFIRSLKSYKLHRTASPFDRRVT
SLEWHPTHPTTVAVGSKGGDIILWDYDVQNKTSFIQGMGPGDAITGMKFN
QFNTNQLFVSSIRGATTLRDFSGSVIQVFAKTDSWDYWYCCVDVSVSRQM
LATGDSTGRLLLLGLDGHEIFKEKLHKAKVTHAEFNPRCDWLMATSSVDA
TVKLWDLRNIKDKNSYIAEMPHEKPVNAAYFNPTDSTKLLTTDQRNEIRV
YSSYDWSKPDQIIIHPHRQFQHLTPIKATWHPMYDLIVAGRYPDDQLLLN
DKRTIDIYDANSGGLVHQLRDPNAAGIISLNKFSPTGDVLASGMGFNILI
WNRE

Ligand information

>4a09 Chain H (length=15) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

cctgctcctttcacc

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4a09 The Molecular Basis of Crl4(Ddb2/Csa) Ubiquitin Ligase Architecture, Targeting, and Activation
Resolution	3.1 Å
Binding residue (original residue number in PDB)	R369 F371 Q372 Y393 R404 G427 I428 F447
Binding residue (residue number reindexed from 1)	R268 F270 Q271 Y292 R303 G326 I327 F346

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003684	damaged DNA binding

	Biological Process
GO:0006281	DNA repair

	Cellular Component
GO:0005634	nucleus
GO:0080008	Cul4-RING E3 ubiquitin ligase complex

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Cellular Component

External links

PDB	RCSB:4a09, PDBe:4a09, PDBj:4a09
PDBsum	4a09
PubMed	22118460
UniProt	Q2YDS1\|DDB2_DANRE DNA damage-binding protein 2 (Gene Name=ddb2)

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