Structure of PDB 3w5k Chain B Binding Site BS02

PDB	3w5k Structural basis for the selective nuclear import of the C2H2 zinc-finger protein Snail by importin beta.
Resolution	2.6 Å
Binding residue (original residue number in PDB)	C182 H198 H202
Binding residue (residue number reindexed from 1)	C30 H46 H50
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0019900	kinase binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding
GO:0070888	E-box binding
GO:1990837	sequence-specific double-stranded DNA binding

	Biological Process
GO:0000122	negative regulation of transcription by RNA polymerase II
GO:0001649	osteoblast differentiation
GO:0001707	mesoderm formation
GO:0001837	epithelial to mesenchymal transition
GO:0003180	aortic valve morphogenesis
GO:0003198	epithelial to mesenchymal transition involved in endocardial cushion formation
GO:0006355	regulation of DNA-templated transcription
GO:0006357	regulation of transcription by RNA polymerase II
GO:0007219	Notch signaling pathway
GO:0007498	mesoderm development
GO:0010631	epithelial cell migration
GO:0010718	positive regulation of epithelial to mesenchymal transition
GO:0010957	negative regulation of vitamin D biosynthetic process
GO:0030335	positive regulation of cell migration
GO:0031069	hair follicle morphogenesis
GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator
GO:0045892	negative regulation of DNA-templated transcription
GO:0045893	positive regulation of DNA-templated transcription
GO:0060021	roof of mouth development
GO:0060070	canonical Wnt signaling pathway
GO:0060536	cartilage morphogenesis
GO:0060707	trophoblast giant cell differentiation
GO:0060806	negative regulation of cell differentiation involved in embryonic placenta development
GO:0060972	left/right pattern formation
GO:0070828	heterochromatin organization
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
GO:2000810	regulation of bicellular tight junction assembly

	Cellular Component
GO:0001650	fibrillar center
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005721	pericentric heterochromatin
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0043231	intracellular membrane-bounded organelle

External links

PDB	RCSB:3w5k, PDBe:3w5k, PDBj:3w5k
PDBsum	3w5k
PubMed	24699649
UniProt	O95863\|SNAI1_HUMAN Zinc finger protein SNAI1 (Gene Name=SNAI1)