Structure of PDB 3vpd Chain B Binding Site BS02

Receptor Information
>3vpd Chain B (length=268) Species: 274 (Thermus thermophilus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MLAILYDRIRPDERMLFERAEALGLPYKKVYVPALPMVLGERPEALEGVT
VALERCVSQSRGLAAARYLTALGIPVVNRPEVIEACGDKWATSVALAKAG
LPQPKTALATDREEALRLMEAFGYPVVLKPVIGSWGRLLAKVTDRAAAEA
LLEHKEVLGGFQHQLFYIQEYVEKPGRDIRVFVVGERAIAAIYRQAENCP
LTEEIARLSVGAAEAVGGGVVAVDLFESERGLLVNEVNHTMEFKNSVHTT
GVDIPGEILRYAWEVARG
Ligand information
Ligand IDBUA
InChIInChI=1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)
InChIKeyFERIUCNNQQJTOY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7CCCC(=O)O
CACTVS 3.385CCCC(O)=O
FormulaC4 H8 O2
Namebutanoic acid
ChEMBLCHEMBL14227
DrugBankDB03568
ZINCZINC000000895132
PDB chain3vpd Chain B Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3vpd Lysine and arginine biosyntheses mediated by a common carrier protein in Sulfolobus.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		F256 K257 N258 S259
Binding residue
(residue number reindexed from 1)		F243 K244 N245 S246
Annotation score1
Enzymatic activity
Enzyme Commision number 6.3.2.43: [amino-group carrier protein]--L-2-aminoadipate ligase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0018169 ribosomal S6-glutamic acid ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0009085 lysine biosynthetic process
GO:0009432 SOS response
GO:0018410 C-terminal protein amino acid modification
GO:0019878 lysine biosynthetic process via aminoadipic acid
GO:0036211 protein modification process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3vpd, PDBe:3vpd, PDBj:3vpd
PDBsum3vpd
PubMed23434852
UniProtQ5SH23|LYSX_THET8 Alpha-aminoadipate--LysW ligase LysX (Gene Name=lysX)

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