Structure of PDB 3twt Chain B Binding Site BS02
Receptor Information
>3twt Chain B (length=155) Species:
9606
(Homo sapiens) [
Search protein sequence
] [
Download receptor structure
] [
Download structure with residue number starting from 1
] [
View receptor structure
]
GNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIRQSTPLHFAAGYNRV
SVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVAD
LWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDI
QDLLR
Ligand information
>3twt Chain F (length=13) Species:
9606
(Homo sapiens) [
Search peptide sequence
] [
Download ligand structure
] [
Download structure with residue number starting from 1
] [
View ligand structure
]
LQRPPPIGQSFRS
Receptor-Ligand Complex Structure
Global view
Local view
Structure summary
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
[
Spin on
] [
Spin off
] [
Reset
]
[
High quality
] [
Low quality
]
[
White background
] [
Black background
]
PDB
3twt
Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
Resolution
1.85 Å
Binding residue
(original residue number in PDB)
R525 F532 G535 Y536 L560 N565 Y569 H571 D589 W591 F593 E598 K604
Binding residue
(residue number reindexed from 1)
R36 F43 G46 Y47 L71 N76 Y80 H82 D100 W102 F104 E109 K115
Enzymatic activity
Enzyme Commision number
2.4.2.-
2.4.2.30
: NAD(+) ADP-ribosyltransferase.
External links
PDB
RCSB:3twt
,
PDBe:3twt
,
PDBj:3twt
PDBsum
3twt
PubMed
22153077
UniProt
Q9H2K2
|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)
[
Back to BioLiP
]
