Structure of PDB 3twr Chain B Binding Site BS02
Receptor Information
>3twr Chain B (length=157) Species:
9606
(Homo sapiens) [
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GNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYN
RVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNV
ADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDT
DIQDLLR
Ligand information
>3twr Chain F (length=13) Species:
9606
(Homo sapiens) [
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LQRSPPDGQSFRS
Receptor-Ligand Complex Structure
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PDB
3twr
Structural basis and sequence rules for substrate recognition by tankyrase explain the basis for cherubism disease.
Resolution
1.55 Å
Binding residue
(original residue number in PDB)
R525 S527 F532 G535 Y536 L560 N565 S568 Y569 H571 D589 W591 F593 E598 K604
Binding residue
(residue number reindexed from 1)
R38 S40 F45 G48 Y49 L73 N78 S81 Y82 H84 D102 W104 F106 E111 K117
Enzymatic activity
Enzyme Commision number
2.4.2.-
2.4.2.30
: NAD(+) ADP-ribosyltransferase.
External links
PDB
RCSB:3twr
,
PDBe:3twr
,
PDBj:3twr
PDBsum
3twr
PubMed
22153077
UniProt
Q9H2K2
|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)
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