Structure of PDB 3tii Chain B Binding Site BS02

Receptor Information
>3tii Chain B (length=313) Species: 8364 (Xenopus tropicalis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSFTYTFVVRDENSTVYAEVAKILLASGQWKRLKRDNPKFNLMLGERNRL
PFGRLGHEPGLVQLVNYYRGADKLCRKASLVKLIKTSPELTETCTWFPES
YVIYPDEREEFRSSFNKKKENEEGNVWIAKSSSEGILISSDATELLDFID
NQGQVHVIQKYLESPLLLEPGHRKFDIRSWVLVDNQYNIYLYREGVLRTS
SEPYNEMFFEEFNQYLVTSLNINLENSILCQIKEIIRVCLSCLEPAISTK
YLPYHSFQLFGFDFMVDKNLKVWLIEVNGAPACAQKLYAELCKGIVDLAI
SSVFPLNNVFIKL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3tii Chain B Residue 381 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3tii Tubulin tyrosine ligase structure reveals adaptation of an ancient fold to bind and modify tubulin.
Resolution2.5 Å
Binding residue
(original residue number in PDB)		Y14 N63 Q313 L314
Binding residue
(residue number reindexed from 1)		Y17 N66 Q258 L259
Annotation score1
Enzymatic activity
Enzyme Commision number 6.3.2.25: tubulin--tyrosine ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0036211 protein modification process

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Molecular Function
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Biological Process
External links
PDB RCSB:3tii, PDBe:3tii, PDBj:3tii
PDBsum3tii
PubMed22020298
UniProtF6Z895

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