Structure of PDB 3thz Chain B Binding Site BS02

Receptor Information
>3thz Chain B (length=846) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SKSIYTPLELQYIEMKQQHKDAVLCVECGYKYRFFGEDAEIAARELNIYC
HLDHNFMTASIPTHRLFVHVRRLVAKGYKVGVVKQTETAALKAIGDNRSS
LFSRKLTALYTKSTLIGEDVNPTDTSTSYLLCISENKKKKGNIFIGIVGV
QPATGEVVFDSFQDSASRSELETRMSSLQPVELLLPSALSEQTEALIHRA
TSVSVQDDRIRVERMDNIYFEYSHAFQAVTEFYAKGIVNLEKPVICSLAA
IIKYLKEFNLEKMLSKPENFKQLSSKMEFMTINGTTLRNLEILQNQTDMK
TKGSLLWVLDHTKTSFGRRKLKKWVTQPLLKLREINARLDAVSEVLHSES
SVFGQIENHLRKLPDIERGLCSIYHKKCSTQEFFLIVKTLYHLKSEFQAI
IPAVNSHIQSDLLRTVILEIPELLSPVEHYLKILNEQAAKVGDKTELFKD
LSDFPLIKKRKDEIQGVIDEIRMHLQEIRKILKNPSAQYVTVSGQEFMIE
IKNSAVSCIPTDWVKVGSTKAVSRFHSPFIVENYRHLNQLREQLVLDCSA
EWLDFLEKFSEHYHSLCKAVHHLATVDCIFSLAKVAKQGDYCRPTVQEER
KIVIKNGRHPVIDVLLGEQDQYVPNNTDLSEDSERVMIITGPNMGGKSSY
IKQVALITIMAQIGSYVPAEEATIGIVDGIFTRMGAAGRSTFMEELTDTA
EIIRKATSQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTH
YPPVCELEKNYSHQVGNYHMGFLVFVTFLYQITRGIAARSYGLNVAKLAD
VPGEILKKAAHKSKELEGLINTKRKRLKYFAKLWTMHNAQDLQKWT
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3thz Mechanism of mismatch repair revealed by human MutS bound to unpaired DNA loops
Resolution4.3 Å
Binding residue
(original residue number in PDB)		Y245 I263 Y264 S275 P277 R280 H284 S314 T737 V738 S739 T765 K766 R770
Binding residue
(residue number reindexed from 1)		Y30 I48 Y49 S60 P62 R65 H69 S99 T491 V492 S493 T519 K520 R524
Binding affinityPDBbind-CN: Kd=0.1nM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0030983 mismatched DNA binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0006298 mismatch repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3thz, PDBe:3thz, PDBj:3thz
PDBsum3thz
PubMed22179786
UniProtP20585|MSH3_HUMAN DNA mismatch repair protein Msh3 (Gene Name=MSH3)

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