BioLiP

Receptor Information

>3thy Chain B (length=857) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KSIYTPLELQYIEMKQQHKDAVLCVECGYKYRFFGEDAEIAARELNIYCH
LDHNFMTASIPTHRLFVHVRRLVAKGYKVGVVKQTETAALKAIGDNRSSL
FSRKLTALYTKSTLIGEDVNPLIKLAVNVDEIMTDTSTSYLLCISENKNI
FIGIVGVQPATGEVVFDSFQDSASRSELETRMSSLQPVELLLPSALSEQT
EALIHRATSVSVQDDRIRVERMDNIYFEYSHAFQAVTEFYAKGIVNLEKP
VICSLAAIIKYLKEFNLEKMLSKPENFKQLSSKMEFMTINGTTLRNLEIL
QNQTDMKTKGSLLWVLDHTKTSFGRRKLKKWVTQPLLKLREINARLDAVS
EVLHSESSVFGQIENHLRKLPDIERGLCSIYHKKCSTQEFFLIVKTLYHL
KSEFQAIIPAVNSHIQSDLLRTVILEIPELLSPVEHYLKILNEQAAKVGD
KTELFKDLSDFPLIKKRKDEIQGVIDEIRMHLQEIRKILKNPSAQYVTVS
GQEFMIEIKNSAVSCIPTDWVKVGSTKAVSRFHSPFIVENYRHLNQLREQ
LVLDCSAEWLDFLEKFSEHYHSLCKAVHHLATVDCIFSLAKVAKQGDYCR
PTVQEERKIVIKNGRHPVIDVLLGEQDQYVPNNTDLSEDSERVMIITGPN
MGGKSSYIKQVALITIMAQIGSYVPAEEATIGIVDGIFTRMGASTFMEEL
TDTAEIIRKATSQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTL
FVTHYPPVCELEKNYSHQVGNYHMGFLVSFVTFLYQITRGIAARSYGLNV
AKLADVPGEILKKAAHKSKELEGLINTKRKRLKYFAKLWTMHNAQDLQKW
TEEFNME

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	3thy Mechanism of mismatch repair revealed by human MutSbeta bound to unpaired DNA loops
Resolution	2.894 Å
Binding residue (original residue number in PDB)	Y245 K246 I263 Y264 S275 P277 H279 R280 H284 S314 V738 S739 T765 K766 R770
Binding residue (residue number reindexed from 1)	Y29 K30 I47 Y48 S59 P61 H63 R64 H68 S98 V499 S500 T526 K527 R531

Enzyme Commision number

	Molecular Function
GO:0005524	ATP binding
GO:0030983	mismatched DNA binding
GO:0140664	ATP-dependent DNA damage sensor activity

	Biological Process
GO:0006298	mismatch repair

PDB	RCSB:3thy, PDBe:3thy, PDBj:3thy
PDBsum	3thy
PubMed	22179786
UniProt	P20585\|MSH3_HUMAN DNA mismatch repair protein Msh3 (Gene Name=MSH3)

[Back to BioLiP]

Structure of PDB 3thy Chain B Binding Site BS02