Structure of PDB 3thx Chain B Binding Site BS02

Receptor Information
>3thx Chain B (length=852) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSIYTPLELQYIEMKQQHKDAVLCVECGYKYRFFGEDAEIAARELNIYCH
LDHNFMTASIPTHRLFVHVRRLVAKGYKVGVVKQTETAALKAIGDNRSSL
FSRKLTALYTKSTLIGEDVNPLIKLAVNVDEIMTDTSTSYLLCISENKNI
FIGIVGVQPATGEVVFDSFQDSASRSELETRMSSLQPVELLLPSALSEQT
EALIHRATSVSVQDDRIRVERMDNIYFEYSHAFQAVTEFYAIVNLEKPVI
CSLAAIIKYLKEFNLEKMLSKPENFKQLSSKMEFMTINGTTLRNLEILQN
QTDMKTKGSLLWVLDHTKTSFGRRKLKKWVTQPLLKLREINARLDAVSEV
LHSESSVFGQIENHLRKLPDIERGLCSIYHKKCSTQEFFLIVKTLYHLKS
EFQAIIPAVNSHIQSDLLRTVILEIPELLSPVEHYLKILNEQAAKVGDKT
ELFKDLSDFPLIKKRKDEIQGVIDEIRMHLQEIRKILKNPSAQYVTVSGQ
EFMIEIKNSAVSCIPTDWVKVGSTKAVSRFHSPFIVENYRHLNQLREQLV
LDCSAEWLDFLEKFSEHYHSLCKAVHHLATVDCIFSLAKVAKQGDYCRPT
VQEERKIVIKNGRHPVIDVLLGEQDQYVPNNTDLSEDSERVMIITGPNMG
GKSSYIKQVALITIMAQIGSYVPAEEATIGIVDGIFTRMSTFMEELTDTA
EIIRKATSQSLVILDELGRGTSTHDGIAIAYATLEYFIRDVKSLTLFVTH
YPPVCELEKNYSHQVGNYHMGFLVSVTFLYQITRGIAARSYGLNVAKLAD
VPGEILKKAAHKSKELEGLINTKRKRLKYFAKLWTMHNAQDLQKWTEEFN
ME
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3thx Mechanism of mismatch recognition revealed by human MutSbeta bound to unpaired DNA loops
Resolution2.7 Å
Binding residue
(original residue number in PDB)		Y245 K246 I263 Y264 S275 P277 R280 H284 S314 S739 T765 K766 R770
Binding residue
(residue number reindexed from 1)		Y29 K30 I47 Y48 S59 P61 R64 H68 S98 S498 T524 K525 R529
Binding affinityPDBbind-CN: Kd=70pM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005524 ATP binding
GO:0030983 mismatched DNA binding
GO:0140664 ATP-dependent DNA damage sensor activity
Biological Process
GO:0006298 mismatch repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3thx, PDBe:3thx, PDBj:3thx
PDBsum3thx
PubMed22179786
UniProtP20585|MSH3_HUMAN DNA mismatch repair protein Msh3 (Gene Name=MSH3)

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