Structure of PDB 3sah Chain B Binding Site BS02

Receptor Information
>3sah Chain B (length=382) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SIIRPQLKFREKIDNSNTPFLPKIFIKPNAQKPLPQALSKERREQDMFAH
PYQYELNHFTPADAVLQKPQPQLYRPIEETPCHFISSLDELVELNEKLLN
CQEFAVDLEHHSYRSFLGLTCLMQISTRTEDFIIDTLELRSDMYILNESL
TDPAIVKVFHGADSDIEWLQKDFGLYVVNMFDTHQAARLLNLGRHSLDHL
LKLYCNVDSNKQYQLADWRIRPLPEEMLSAARDDTHYLLYIYDKMRLEMW
ERGNGQPVQLQVVWQRSRDICLKKFIKPIFTDESYLELYRKQKKHLNTQQ
LTAFQLLFAWRDKTARREDESYGYVLPNHMMLKIAEELPKEPQGIIACCN
PVPPLVRQQINEMHLLIQQAREMPLLKSEVAA
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3sah Chain B Residue 2 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3sah Activities of human RRP6 and structure of the human RRP6 catalytic domain.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		E315 D440
Binding residue
(residue number reindexed from 1)		E109 D234
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) D313 E315 D371 A436 D440
Catalytic site (residue number reindexed from 1) D107 E109 D165 A230 D234
Enzyme Commision number 3.1.13.-
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000175 3'-5'-RNA exonuclease activity
GO:0003676 nucleic acid binding
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006139 nucleobase-containing compound metabolic process
GO:0044237 cellular metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3sah, PDBe:3sah, PDBj:3sah
PDBsum3sah
PubMed21705430
UniProtQ01780|EXOSX_HUMAN Exosome complex component 10 (Gene Name=EXOSC10)

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