Structure of PDB 3r3l Chain B Binding Site BS02

Receptor Information
>3r3l Chain B (length=514) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSFLWTQSLRRELSGYCSNIKLQVVKDAQALLHGLDFSEVSNVQRLMRKQ
RRDDSDLKRLRDLNQAVNNLVELKSTQQKSVLRVGTLSSDDLLTLAADLE
KLKSKVTRTERPLSSGVYMGNLSSQQLDQRRALLNLIGMDGVVRVWDVKN
AELLNNQFGTMPSLTLACLTKQGQVDLNDVVQALTDLGLIYTAKYPNTSD
LDRLTQSHPILNMIDTKKSSLNISGYNFSLGAAVKAGACMLDGGNMLETI
KVSPQSMDGILKSILKVKRALGMFVSDTPGERNPYENILYKICLSGDGWP
YIASRTSIVGRAWENTVVDLGLTYSQLMTLKDAMLQLDPNAKTWMDIEGR
PEDPVEVALYQPISGCYIHFFREPTDLKQFKQDAKYSHGIDIADLFAAQP
GLTSAVIEALPRNMVITCQGSEDIKKLLESQGRKDIKLIDIALSKIDSRK
FENAVWDQYKDLCHMHTGVVVEKKKEEITPHCALMDCIMFDAAVSGGLNT
LVLRAVLPRDMVFR
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain3r3l Chain B Residue 583 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3r3l Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy.
Resolution2.449 Å
Binding residue
(original residue number in PDB)		D389 E391 D533
Binding residue
(residue number reindexed from 1)		D346 E348 D486
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.13.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0019049 virus-mediated perturbation of host defense response
GO:0039689 negative stranded viral RNA replication
GO:0039696 RNA-templated viral transcription
GO:0039724 symbiont-mediated suppression of host cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity
Cellular Component
GO:0019013 viral nucleocapsid
GO:0019029 helical viral capsid
GO:0030430 host cell cytoplasm
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3r3l, PDBe:3r3l, PDBj:3r3l
PDBsum3r3l
PubMed21917929
UniProtQ9DQX7

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