Structure of PDB 3qi5 Chain B Binding Site BS02

Receptor Information
>3qi5 Chain B (length=210) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHMTRLGLEFFDQPAVPLARAFLGQVLVRRLPNGTELRGRIVETEAYLG
PEDEAAHSRGGRQTPRNRGMFMKPGTLYVYIIYGMYFCMNISSQGDGACV
LLRALEPLEGLETMRQLRSTLRKGTRVLKDRELCSGPSKLCQALAINKSF
DQRDLAQDEAVWLERGPLEPSEPAVVAAARVGVAGEWARKPLRFYVRGSP
WVSVVDRVAE
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3qi5 Structural Basis for the Inhibition of Human Alkyladenine DNA Glycosylase (AAG) by 3,N4-Ethenocytosine-containing DNA.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		T143 P144 R145 I160 Y162 G163 M164 K229
Binding residue
(residue number reindexed from 1)		T64 P65 R66 I81 Y83 G84 M85 K148
Binding affinityPDBbind-CN: Kd=21nM
Enzymatic activity
Enzyme Commision number 3.2.2.21: DNA-3-methyladenine glycosylase II.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0003905 alkylbase DNA N-glycosylase activity
Biological Process
GO:0006284 base-excision repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3qi5, PDBe:3qi5, PDBj:3qi5
PDBsum3qi5
PubMed21349833
UniProtP29372|3MG_HUMAN DNA-3-methyladenine glycosylase (Gene Name=MPG)

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