Structure of PDB 3qdz Chain B Binding Site BS02

Receptor Information
>3qdz Chain B (length=251) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRNI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETKGQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDSG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
F
Ligand information
Receptor-Ligand Complex Structure
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PDB3qdz Molecular dissection of Na+ binding to thrombin.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		H57 W60D I174 D189 E192 S195 W215 G216 E217 R221A
Binding residue
(residue number reindexed from 1)		H43 W50 I173 D193 E196 S199 W221 G222 E223 R227
Enzymatic activity
Catalytic site (original residue number in PDB) H57 N102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 N99 E196 G197 D198 S199 G200
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:3qdz, PDBe:3qdz, PDBj:3qdz
PDBsum3qdz
PubMed
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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