Structure of PDB 3qc3 Chain B Binding Site BS02

Receptor Information
>3qc3 Chain B (length=225) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GMASGCKIGPSILNSDLANLGAECLRMLDSGADYLHLDVMDGHFVPNITF
GHPVVESLRKQLGQDPFFDMHMMVSKPEQWVKPMAVAGANQYTFHLEATE
NPGALIKDIRENGMKVGLAIKPGTSVEYLAPWANQIDMALVMTVEPGFGG
QKFMEDMMPKVHWLRTQFPSLDIEVDGGVGPDTVHKCAEAGANMIVSGSA
IMRSEDPRSVINLLRNVCSEAAQKR
Ligand information
Ligand IDFE
InChIInChI=1S/Fe/q+3
InChIKeyVTLYFUHAOXGGBS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		[Fe+3]
FormulaFe
NameFE (III) ION
ChEMBL
DrugBankDB13949
ZINC
PDB chain3qc3 Chain B Residue 231 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3qc3 Crystal structure of a D-ribulose-5-phosphate-3-epimerase (NP_954699) from HOMO SAPIENS at 2.20 A resolution
Resolution2.2 Å
Binding residue
(original residue number in PDB)		H35 D37 H70 D175
Binding residue
(residue number reindexed from 1)		H36 D38 H71 D176
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) S10 H35 D37 M39 H70 M72 M141 D175
Catalytic site (residue number reindexed from 1) S11 H36 D38 M40 H71 M73 M142 D176
Enzyme Commision number 5.1.3.1: ribulose-phosphate 3-epimerase.
Gene Ontology
Molecular Function
GO:0004750 D-ribulose-phosphate 3-epimerase activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006098 pentose-phosphate shunt
GO:0009052 pentose-phosphate shunt, non-oxidative branch
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular exosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3qc3, PDBe:3qc3, PDBj:3qc3
PDBsum3qc3
PubMed
UniProtQ96AT9|RPE_HUMAN Ribulose-phosphate 3-epimerase (Gene Name=RPE)

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