Structure of PDB 3q8p Chain B Binding Site BS02

Receptor Information
>3q8p Chain B (length=380) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVK
KLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFD
ENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVG
SQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESC
QHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGIS
VAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLA
SLLNRVCQDGRKPHTVRLIIRRYSGRESRQCPIPSHVIQKLNYDVMTPMV
DILMKLFRNMVNVKMPFHLTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3q8p Unique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iota.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		L123 E127 K207 P240 G241 G243 K245 T246 E358 S359 R360 Q361
Binding residue
(residue number reindexed from 1)		L97 E101 K181 P214 G215 G217 K219 T220 E327 S328 R329 Q330
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3q8p, PDBe:3q8p, PDBj:3q8p
PDBsum3q8p
PubMed21300901
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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