Structure of PDB 3q0a Chain B Binding Site BS02

Receptor Information
>3q0a Chain B (length=1094) Species: 10752 (Enquatrovirus N4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TEELKEGIDAVYPSLVGTADSKAEGIKNYFKLSFTLPEEQKSRTVGSEAP
LKDVAQALSSRARYELFTEKETANPAFNGEVIKRYKELMEHGEGIADILR
SRLAKFLNTKDVGKRFAQGTEANRWVGGKLLNIVEQDGDTFKYNEQLLQT
AVLAGLQWRLTATSNTAIKDAKDVAAITGIDQALLPEGLVEQFDTGMTLT
EAVSSLAQKIESYWGLSRNPNAPLGYTKGIPTAMAAEILAAFVESTDVVE
NIVDMSEIDPDNKKTIGLYTITELDSFDPINSFPTAIEEAVLVNPTEKMF
FGDDIPPVANTQLRNPAVRNTPEQKAALKAEQATEFYVHTPMVQFYETLG
KDRILELMGAGTLNKELLNDNHAKSLEGKNRSVEDSYNQLFSVIEQVRAQ
SEDISTVPIHYAYNMTRVGRMQMLGKYNPQSAKLVREAILPTKATLDLSN
QNNEDFSAFQLGLAQALDIKVHTMTREVMSDELTKLLEGNLKPAIDMMVE
FNTTGSLPENAVDVLNTALGDRKSFVALMALMEYSRYLVAEDKSAFVTPL
YVEADGVTNGPINAMMLMTGGLFTPDWIRNIAKGGLFIGSPNKTMNEHRS
TADNNDLYQASTNALMESLGKLRSNYASNMPIQSQIDSLLSLMDLFLPDI
NLGENGALELKRGIAKNPLTITIYGSGARGIAGKLVSSVTDAIYERMSDV
LKARAKDPNISAAMAMFGKQAASEAHAEELLARFLKDMETLTSTVPVKRK
GVLELQSTGTGAKGKINPKTYTIKGEQLKALQENMLHFFVEPLRNGITQT
VGESLVYSTEQLQKATQIQSVVLEDMFKQRVQEKLAEKAKDPTWKKGDFL
TQKELNDIQASLNNLAPMIETGSQTFYIAGSENAEVANQVLATNLDDRMR
VPMSIYAPAQAGVAGIPFMTIGTGDGMMMQTLSTMKGAPKNTLKIFDGMN
IGLNDITDASRKANEAVYTSWQGNPIKNVYESYAKFMKNVDFSKLSPEAL
EAIGKSALEYDQRENATVDDIANAASLIERNLRNIALGVDIRHKVLDKVN
LSIDQMAAVGAPYQNNGKIDLSNMTPEQQADELNKLFREELEAR
Ligand information
Ligand IDGTP
InChIInChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
InChIKeyXKMLYUALXHKNFT-UUOKFMHZSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6c1nc2c(n1[C@H]3[C@@H]([C@@H]([C@H](O3)CO[P@](=O)(O)O[P@](=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
CACTVS 3.370NC1=Nc2n(cnc2C(=O)N1)[C@@H]3O[C@H](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[C@@H](O)[C@H]3O
CACTVS 3.370NC1=Nc2n(cnc2C(=O)N1)[CH]3O[CH](CO[P](O)(=O)O[P](O)(=O)O[P](O)(O)=O)[CH](O)[CH]3O
OpenEye OEToolkits 1.7.6c1nc2c(n1C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O)N=C(NC2=O)N
ACDLabs 12.01O=P(O)(O)OP(=O)(O)OP(=O)(O)OCC3OC(n2cnc1c2N=C(N)NC1=O)C(O)C3O
FormulaC10 H16 N5 O14 P3
NameGUANOSINE-5'-TRIPHOSPHATE
ChEMBLCHEMBL1233147
DrugBankDB04137
ZINCZINC000060094177
PDB chain3q0a Chain D Residue 26 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3q0a X-ray crystal structures elucidate the nucleotidyl transfer reaction of transcript initiation using two nucleotides.
Resolution2.69 Å
Binding residue
(original residue number in PDB)		R424 K437 F950 D951
Binding residue
(residue number reindexed from 1)		R420 K433 F946 D947
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
External links
PDB RCSB:3q0a, PDBe:3q0a, PDBj:3q0a
PDBsum3q0a
PubMed21321236
UniProtQ859P9|RPOLV_BPN4 Virion DNA-directed RNA polymerase (Gene Name=50)

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