Structure of PDB 3nmx Chain B Binding Site BS02

Receptor Information
>3nmx Chain B (length=325) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HHHMLHLLEQIRAYCETCWEWQEAPMPAPVEHQICPAVCVLMKLSFDEEH
RHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGD
VANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKT
LREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGA
LAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCL
QTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIH
SKHKMIAMGSAAALRNLMANRPAKY
Ligand information
Receptor-Ligand Complex Structure
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PDB3nmx Structural basis for the recognition of Asef by adenomatous polyposis coli.
Resolution2.3 Å
Binding residue
(original residue number in PDB)		C451 K455 F458
Binding residue
(residue number reindexed from 1)		C39 K43 F46
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008013 beta-catenin binding
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:3nmx, PDBe:3nmx, PDBj:3nmx
PDBsum3nmx
PubMed21788986
UniProtP25054|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

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