Structure of PDB 3mx6 Chain B Binding Site BS02

Receptor Information
>3mx6 Chain B (length=260) Species: 782 (Rickettsia prowazekii) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSMIKIHTEKDFIKMRAAGKLAAETLDFITDHVKPNVTTNSLNDLCHNFI
TSHNAIPAPLNYKGFPKSICTSINHVVCHGIPNDKPLKNGDIVNIDVTVI
LDGWYGDTSRMYYVGDVAIKPKRLIQVTYDAMMKGIEVVRPGAKLGDIGY
AIQSYAEKHNYSVVRDYTGHGIGRVFHDKPSILNYGRNGTGLTLKEGMFF
TVEPMINAGNYDTILSKLDGWTVTTRDKSLSAQFEHTIGVTKDGFEIFTL
SPKKLDYPPY
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain3mx6 Chain B Residue 259 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3mx6 Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents.
Resolution1.7 Å
Binding residue
(original residue number in PDB)
D105 H168 T199 E201 E233
Binding residue
(residue number reindexed from 1)
D107 H170 T201 E203 E235
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) D94 D105 H168 H175 E201 E233
Catalytic site (residue number reindexed from 1) D96 D107 H170 H177 E203 E235
Enzyme Commision number 3.4.11.18: methionyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0004239 initiator methionyl aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0046872 metal ion binding
GO:0046914 transition metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function

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Biological Process
External links
PDB RCSB:3mx6, PDBe:3mx6, PDBj:3mx6
PDBsum3mx6
PubMed28089350
UniProtQ9ZCD3|MAP1_RICPR Methionine aminopeptidase (Gene Name=map)

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