Structure of PDB 3mx6 Chain B Binding Site BS02
Receptor Information
>3mx6 Chain B (length=260) Species:
782
(Rickettsia prowazekii) [
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GSMIKIHTEKDFIKMRAAGKLAAETLDFITDHVKPNVTTNSLNDLCHNFI
TSHNAIPAPLNYKGFPKSICTSINHVVCHGIPNDKPLKNGDIVNIDVTVI
LDGWYGDTSRMYYVGDVAIKPKRLIQVTYDAMMKGIEVVRPGAKLGDIGY
AIQSYAEKHNYSVVRDYTGHGIGRVFHDKPSILNYGRNGTGLTLKEGMFF
TVEPMINAGNYDTILSKLDGWTVTTRDKSLSAQFEHTIGVTKDGFEIFTL
SPKKLDYPPY
Ligand information
Ligand ID
MN
InChI
InChI=1S/Mn/q+2
InChIKey
WAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mn+2]
CACTVS 3.341
[Mn++]
Formula
Mn
Name
MANGANESE (II) ION
ChEMBL
DrugBank
DB06757
ZINC
PDB chain
3mx6 Chain B Residue 259 [
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Receptor-Ligand Complex Structure
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PDB
3mx6
Rickettsia prowazekii methionine aminopeptidase as a promising target for the development of antibacterial agents.
Resolution
1.7 Å
Binding residue
(original residue number in PDB)
D105 H168 T199 E201 E233
Binding residue
(residue number reindexed from 1)
D107 H170 T201 E203 E235
Annotation score
4
Enzymatic activity
Catalytic site (original residue number in PDB)
D94 D105 H168 H175 E201 E233
Catalytic site (residue number reindexed from 1)
D96 D107 H170 H177 E203 E235
Enzyme Commision number
3.4.11.18
: methionyl aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177
aminopeptidase activity
GO:0004239
initiator methionyl aminopeptidase activity
GO:0008235
metalloexopeptidase activity
GO:0046872
metal ion binding
GO:0046914
transition metal ion binding
GO:0070006
metalloaminopeptidase activity
Biological Process
GO:0006508
proteolysis
View graph for
Molecular Function
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Biological Process
External links
PDB
RCSB:3mx6
,
PDBe:3mx6
,
PDBj:3mx6
PDBsum
3mx6
PubMed
28089350
UniProt
Q9ZCD3
|MAP1_RICPR Methionine aminopeptidase (Gene Name=map)
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