Structure of PDB 3mdr Chain B Binding Site BS02

Receptor Information
>3mdr Chain B (length=425) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RVLQDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSK
MYRALQTVFGERLFGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETF
NEKAEQLVEILEAKADGQTPVSMQDMLTYTAMDILAKAAFGMETSMLLGA
QKPLSQAVKLMLEGITASRNTKRKQLREVRESIRFLRQVGRDWVQRRREA
LKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFFIAGHETSANHLAFT
VMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKESLRLY
PPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPD
RFGPGAPKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVP
GQRFGLQEQATLKPLDPVLCTLRPR
Ligand information
Ligand IDGJZ
InChIInChI=1S/C9H11N/c10-9-6-8(9)7-4-2-1-3-5-7/h1-5,8-9H,6,10H2/t8-,9+/m0/s1
InChIKeyAELCINSCMGFISI-DTWKUNHWSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0c1ccc(cc1)[C@@H]2C[C@H]2N
CACTVS 3.370N[CH]1C[CH]1c2ccccc2
ACDLabs 12.01c1cccc(c1)C2CC2N
OpenEye OEToolkits 1.7.0c1ccc(cc1)C2CC2N
CACTVS 3.370N[C@@H]1C[C@H]1c2ccccc2
FormulaC9 H11 N
Name(1R,2S)-2-phenylcyclopropanamine
ChEMBLCHEMBL1179
DrugBank
ZINCZINC000001482197
PDB chain3mdr Chain B Residue 506 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3mdr Structural basis of drug binding to CYP46A1, an enzyme that controls cholesterol turnover in the brain.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		F121 A302 T306
Binding residue
(residue number reindexed from 1)		F64 A238 T242
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) T306 F430 C437
Catalytic site (residue number reindexed from 1) T242 F366 C373
Enzyme Commision number 1.14.14.25: cholesterol 24-hydroxylase.
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0005506 iron ion binding
GO:0008395 steroid hydroxylase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0020037 heme binding
GO:0033781 cholesterol 24-hydroxylase activity
GO:0046872 metal ion binding
GO:0062184 testosterone 16-beta-hydroxylase activity
Biological Process
GO:0006699 bile acid biosynthetic process
GO:0006707 cholesterol catabolic process
GO:0006805 xenobiotic metabolic process
GO:0007399 nervous system development
GO:0008203 cholesterol metabolic process
GO:0008207 C21-steroid hormone metabolic process
GO:0016125 sterol metabolic process
GO:0042448 progesterone metabolic process
GO:1900271 regulation of long-term synaptic potentiation
GO:1903044 protein localization to membrane raft
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0030425 dendrite
GO:0042995 cell projection
GO:0045202 synapse
GO:0098793 presynapse
GO:0098794 postsynapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3mdr, PDBe:3mdr, PDBj:3mdr
PDBsum3mdr
PubMed20667828
UniProtQ9Y6A2|CP46A_HUMAN Cholesterol 24-hydroxylase (Gene Name=CYP46A1)

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