Structure of PDB 3lu9 Chain B Binding Site BS02

Receptor Information
>3lu9 Chain B (length=251) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETKGQ
PSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDACEGDAG
GPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWIQKVIDQ
F
Ligand information
>3lu9 Chain F (length=25) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
ATNATLDPRSFLLRNPNDKYEPFWE
Receptor-Ligand Complex Structure
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PDB3lu9 Crystal structure of thrombin bound to the uncleaved extracellular fragment of PAR1.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		D186A E186B
Binding residue
(residue number reindexed from 1)		D187 E188
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 A195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E196 G197 D198 A199 G200
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:3lu9, PDBe:3lu9, PDBj:3lu9
PDBsum3lu9
PubMed20236938
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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