Structure of PDB 3l01 Chain B Binding Site BS02

Receptor Information

>3l01 Chain B (length=428) Species: 29292 (Pyrococcus abyssi)

RHMKVLLLGFEFLPVKVGGLAEALTAISEALASLGHEVLVFTPSHGRFQG
EEIGKIRVFGEEVQVKVSYEERGNLRIYRIGGGLLDSEDVYGPGWDGLIR
KAVTFGRASVLLLNDLLREEPLPDVVHFHDWHTVFAGALIKKYFKIPAVF
TIHRLNKSKLPAFYFHEAGLSELAPYPDIDPEHTGGYIADIVTTVSRGYL
IDEWGFFRNFEGKITYVFNGIDCSFWNESYLTGSRDERKKSLLSKFGMDE
GVTFMFIGRFDRGQKGVDVLLKAIEILSSKKEFQEMRFIIIGKGDPELEG
WARSLEEKHGNVKVITEMLSREFVRELYGSVDFVIIPSYFEPFGLVALEA
MCLGAIPIASAVGGLRDIITNETGILVKAGDPGELANAILKALELSRSDL
SKFRENCKKRAMSFSWEKSAERYVKAYA

Ligand information

• Ligand ID: GLC
• InChI: InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
• InChIKey: WQZGKKKJIJFFOK-DVKNGEFBSA-N
• SMILES:
  OpenEye OEToolkits 1.5.0: C(C1C(C(C(C(O1)O)O)O)O)O
  OpenEye OEToolkits 1.5.0: C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
  CACTVS 3.341: OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
  CACTVS 3.341: OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
  ACDLabs 10.04: OC1C(O)C(OC(O)C1O)CO
• Formula: C6 H12 O6
• Name: alpha-D-glucopyranose;
  alpha-D-glucose;
  D-glucose;
  glucose
• ChEMBL: CHEMBL423707
• ZINC: ZINC000003861213
• PDB chain: 3l01 Chain D Residue 2

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3l01 Processivity and Subcellular Localization of Glycogen Synthase Depend on a Non-catalytic High Affinity Glycogen-binding Site.
• Resolution: 2.6 Å
• Binding residue (original residue number in PDB): K157 D176
• Binding residue (residue number reindexed from 1): K159 D178
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.4.1.21: starch synthase.

Gene Ontology

Molecular Function

• GO:0004373 alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity
• GO:0016757 glycosyltransferase activity

External links

• PDB: RCSB:3l01, PDBe:3l01, PDBj:3l01
• PDBsum: 3l01
• PubMed: 21464127
• UniProt: Q9V2J8