Structure of PDB 3kf2 Chain B Binding Site BS02

Receptor Information
>3kf2 Chain B (length=181) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
APITAYAQQTRGLLGCIITSLTGRDKNQVEGEVQIVSTATQTFLATCING
VCWTVYHGAGTRTIASPKGPVIQMYTNVDQDLVGWPAPQGSRSLTPCTCG
SSDLYLVTRHADVIPVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPAGHA
VGLFRAAVCTRGVAKAVDFIPVENLETTMRS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3kf2 Induced-Fit Binding of the Macrocyclic Noncovalent Inhibitor TMC435 to its HCV NS3/NS4A Protease Target
Resolution2.5 Å
Binding residue
(original residue number in PDB)		T4 A5 Y6 A7 Q8 T10 R11 C16 S20 E30 E32 V33 I35 V36 S37 R62 T63 I64 A65
Binding residue
(residue number reindexed from 1)		T4 A5 Y6 A7 Q8 T10 R11 C16 S20 E30 E32 V33 I35 V36 S37 R62 T63 I64 A65
Enzymatic activity
Enzyme Commision number 3.4.21.98: hepacivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0019087 transformation of host cell by virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3kf2, PDBe:3kf2, PDBj:3kf2
PDBsum3kf2
PubMed20166108
UniProtB2Y2M9

[Back to BioLiP]