Structure of PDB 3kex Chain B Binding Site BS02

Receptor Information
>3kex Chain B (length=283) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KVLARIFKETELRKLKVLGSGVFGTVHKGVWIPEGESIKIPVCIKVIEDK
SGRQSFQAVTDHMLAIGSLDHAHIVRLLGLCPGSSLQLVTQYLPLGSLLD
HVRQHRGALGPQLLLNWGVQIAKGMYYLEEHGMVHRNLAARNVLLKSPSQ
VQVADFGVADLLPPDDKQTPIKWMALESIHFGKYTHQSDVWSYGVTVWEL
MTFGAEPYAGLRLAEVPDLLEKGERLAQPQICTIDVYMVMVKCWMIDENI
RPTFKELANEFTRMARDPPRYLVIKREGPGIAP
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3kex Chain B Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3kex Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3.
Resolution2.797 Å
Binding residue
(original residue number in PDB)		N820 D833
Binding residue
(residue number reindexed from 1)		N142 D155
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) N815 A817 R819 N820 D833 D843 T854
Catalytic site (residue number reindexed from 1) N137 A139 R141 N142 D155 D165 T169
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3kex, PDBe:3kex, PDBj:3kex
PDBsum3kex
PubMed20007378
UniProtP21860|ERBB3_HUMAN Receptor tyrosine-protein kinase erbB-3 (Gene Name=ERBB3)

[Back to BioLiP]