Structure of PDB 3ie1 Chain B Binding Site BS02

Receptor Information
>3ie1 Chain B (length=431) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRIVPFGAAREVTGSAHLLLAGGRRVLLDCGMFQGKEEARNHAPFGFDPK
EVDAVLLTHAHLDHVGRLPKLFREGYRGPVYATRATVLLMEIVLEDALKV
MDEPFFGPEDVEEALGHLRPLEYGEWLRLGALSLAFGQAGHLPGSAFVVA
QGEGRTLVYSGDLGNREKDVLPDPSLPPLADLVLAEGTYGDRPHRPYRET
VREFLEILEKTLSQGGKVLIPTFAVERAQEILYVLYTHGHRLPRAPIYLD
SPMAGRVLSLYPRLVRYFSEEVQAHFLQGKNPFRPAGLEVVEHTEASKAL
NRAPGPMVVLAGSGMLAGGRILHHLKHGLSDPRNALVFVGYQPQGGLGAE
IIARPPAVRILGEEVPLRASVHTLGGFSGAAGQDELLDWLQGEPRVVLVH
GEEEKLLALGKLLALRGQEVSLARFGEGVPV
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3ie1 Chain B Residue 449 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3ie1 Crystal structure of H380A mutant TTHA0252 from Thermus thermophilus HB8 complexed with RNA
Resolution2.85 Å
Binding residue
(original residue number in PDB)		D63 H64 D162 H400
Binding residue
(residue number reindexed from 1)		D63 H64 D162 H400
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004521 RNA endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0006364 rRNA processing
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3ie1, PDBe:3ie1, PDBj:3ie1
PDBsum3ie1
PubMed
UniProtQ5SLP1|RNSE_THET8 Ribonuclease TTHA0252 (Gene Name=TTHA0252)

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