Structure of PDB 3hhs Chain B Binding Site BS02

Receptor Information
>3hhs Chain B (length=656) Species: 7130 (Manduca sexta) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DAKNNLLYFFDRPNEPCFMQKGEDKVVFEIPDHYYPDKYKSLSNTLSNRF
GNEATKRIPIRNITLPNLEVPMQLPYNDQFSLFVPKHRTMAAKLIDIFMG
MRDVEDLQSVCSYCQLRINPYMFNYCLSVAILHRPDTKGLSIPTFAETFP
DKFMDSKVFLRAREVSNVVISGSRMPVNVPINYTANTTEPEQRVAYFRED
IGINLHHWHWHLVYPFDSADRSIVNKDRRGELFYYMHQQIIGRYNVERMC
NGLPQVKPFSDFSAPIEEGYFPKLDSQVASRTWPPRFAGSVFRNLDRTVD
QVKIDVRKLFTWRDQFLEAIQKMAIKMPNGRELPLDEVTGIDMLGNLMES
SIISPNRGYYGDLHNMGHVFAAYTHDPDHRHLEQFGVMGDSATAMRDPFF
YRWHRFVDDVFNIYKEKLTPYTNERLDFPGVRVSSVGIEGRPNTLRTLWQ
QSTVELGRGLDFTPRGSVLARFTHLQHDEFQYVIEVNNTTGGNLMGTVRI
FMAPKVDDNGQPMSFNKQRRLMIELDKFSQALRPGTNTIRRRSVDSSVTI
PYERTDFCGCGWPHHMLIPKGTAQGYPVVLFVMISNWNNDRIEQDGSCND
AASYCGIRDRKYPDKQAMGYPFDRKMANDAATLSDFLRPNMAVRDCSIQF
SDTTVE
Ligand information
Ligand IDCU
InChIInChI=1S/Cu/q+2
InChIKeyJPVYNHNXODAKFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Cu+2]
CACTVS 3.341[Cu++]
FormulaCu
NameCOPPER (II) ION
ChEMBL
DrugBankDB14552
ZINC
PDB chain3hhs Chain B Residue 686 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3hhs Crystal structure of Manduca sexta prophenoloxidase provides insights into the mechanism of type 3 copper enzymes.
Resolution1.97 Å
Binding residue
(original residue number in PDB)		H209 H213 H239
Binding residue
(residue number reindexed from 1)		H207 H211 H237
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.18.1: tyrosinase.
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0004503 tyrosinase activity
GO:0005507 copper ion binding
GO:0016491 oxidoreductase activity
GO:0031404 chloride ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006582 melanin metabolic process
GO:0006583 melanin biosynthetic process from tyrosine
GO:0006952 defense response
GO:0035008 positive regulation of melanization defense response
GO:0042438 melanin biosynthetic process
Cellular Component
GO:0005576 extracellular region

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3hhs, PDBe:3hhs, PDBj:3hhs
PDBsum3hhs
PubMed19805072
UniProtO44249|PRP1_MANSE Phenoloxidase subunit 1

[Back to BioLiP]