Structure of PDB 3gyq Chain B Binding Site BS02

Receptor Information
>3gyq Chain B (length=261) Species: 1904 (Streptomyces cyaneus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ANPSDPAVQRIIDVTKPSRSNIKTTLIEDVEPLMHSIAAGVEFIEVYGSD
SSPFPSELLDLCGRQNIPVRLIDSSIVNQLFKGERKAKTFGIARVPRPAR
FGDIASRRGDVVVLDGVKIVGNIGAIVRTSLALGASGIILVDSDITSIAD
RRLQRASRGYVFSLPVVLSGREEAIAFIRDSGMQLMTLKADGDISVKELG
DNPDRLALLFGSEKGGPSDLFEEASSASVSIPMMSQTESLNVSVSLGIAL
HERIDRNLAAN
Ligand information
Ligand IDSAM
InChIInChI=1S/C15H22N6O5S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25)/t7-,8+,10+,11+,14+,27-/m0/s1
InChIKeyMEFKEPWMEQBLKI-FCKMPRQPSA-N
SMILES
SoftwareSMILES
CACTVS 3.341C[S@@+](CC[C@H](N)C([O-])=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23
OpenEye OEToolkits 1.5.0C[S+](CCC(C(=O)[O-])N)CC1C(C(C(O1)n2cnc3c2ncnc3N)O)O
CACTVS 3.341C[S+](CC[CH](N)C([O-])=O)C[CH]1O[CH]([CH](O)[CH]1O)n2cnc3c(N)ncnc23
OpenEye OEToolkits 1.5.0C[S@@+](CC[C@@H](C(=O)[O-])N)C[C@@H]1[C@H]([C@H]([C@@H](O1)n2cnc3c2ncnc3N)O)O
ACDLabs 10.04[O-]C(=O)C(N)CC[S+](C)CC3OC(n2cnc1c(ncnc12)N)C(O)C3O
FormulaC15 H22 N6 O5 S
NameS-ADENOSYLMETHIONINE
ChEMBLCHEMBL1235831
DrugBank
ZINC
PDB chain3gyq Chain B Residue 270 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3gyq Structure of the thiostrepton-resistance methyltransferase-S-adenosyl-L-methionine complex and its interaction with ribosomal RNA
Resolution2.45 Å
Binding residue
(original residue number in PDB)		L195 K196 A197 G218 S219 E220 K221 I238 M240 S246 L247 V249 S252
Binding residue
(residue number reindexed from 1)		L188 K189 A190 G211 S212 E213 K214 I231 M233 S239 L240 V242 S245
Annotation score5
Enzymatic activity
Enzyme Commision number 2.1.1.230: 23S rRNA (adenosine(1067)-2'-O)-methyltransferase.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0008168 methyltransferase activity
GO:0008173 RNA methyltransferase activity
GO:0008649 rRNA methyltransferase activity
GO:0030743 23S rRNA (adenosine(1067)-2'-O)-methyltransferase activity
Biological Process
GO:0006396 RNA processing
GO:0031167 rRNA methylation
GO:0032259 methylation
GO:0046677 response to antibiotic

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3gyq, PDBe:3gyq, PDBj:3gyq
PDBsum3gyq
PubMed19369248
UniProtP18644|TSNR_STRAJ 23S rRNA (adenosine(1067)-2'-O)-methyltransferase (Gene Name=tsnR)

[Back to BioLiP]