Structure of PDB 3gv5 Chain B Binding Site BS02

Receptor Information
>3gv5 Chain B (length=379) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKK
LMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLGFDE
NFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLLVGS
QIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQ
HLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISV
AQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEELLAS
LLNRVCQDGRKPHTVRLIIRRYSGRESRQCPIPSHVIQKLNYDVMTPMVD
ILMKLFRNMVNVKMPFHLTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
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PDB3gv5 Structural basis of error-prone replication and stalling at a thymine base by human DNA polymerase iota
Resolution2.0 Å
Binding residue
(original residue number in PDB)		Q59 K60 Y61 L62 E97 L99 R103 K237 Y244 P299 Q300 S301 F302 S303 E305 S307 R347 R357
Binding residue
(residue number reindexed from 1)		Q32 K33 Y34 L35 E70 L72 R76 K210 Y217 P272 Q273 S274 F275 S276 E278 S280 R320 R325
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3gv5, PDBe:3gv5, PDBj:3gv5
PDBsum3gv5
PubMed19440206
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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