Structure of PDB 3gil Chain B Binding Site BS02

Receptor Information

>3gil Chain B (length=341) Species: 273057 (Saccharolobus solfataricus P2)

GIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEA
RKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIE
IASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVF
AKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGIN
KLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVT
MKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGR
TFPHGISKETAYSESVKLLQKILEEDERKIRRIGVRFSKFI

Ligand information

>3gil Chain J (length=16)

aacgctaccatccaac

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3gil Impact of conformational heterogeneity of OxoG lesions and their pairing partners on bypass fidelity by Y family polymerases.
• Resolution: 2.71 Å
• Binding residue (original residue number in PDB): A1220 R1242 K1243 S1244 G1246 R1247 I1248 T1250 L1293 R1331 R1332
• Binding residue (residue number reindexed from 1): A220 R242 K243 S244 G246 R247 I248 T250 L293 R331 R332

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003677 DNA binding
• GO:0003684 damaged DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006260 DNA replication
• GO:0006261 DNA-templated DNA replication
• GO:0006281 DNA repair
• GO:0006974 DNA damage response
• GO:0042276 error-prone translesion synthesis

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:3gil, PDBe:3gil, PDBj:3gil
• PDBsum: 3gil
• PubMed: 19446528
• UniProt: Q97W02|DPO4_SACS2 DNA polymerase IV (Gene Name=dbh)