Structure of PDB 3fhq Chain B Binding Site BS02

Receptor Information
>3fhq Chain B (length=599) Species: 37930 (Glutamicibacter protophormiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TYNGPLSSHWFPEELAQWEPDSDPDAPFNRSHVPLEPGRVADRVNANADK
DAHLVSLSALNRHTSGVPSQGAPVFYENTFSYWHYTDLMVYWAGSAGEGI
IVPPSADVIDASHRNGVPILGNVFFPPTVYGGQLEWLEQMLEQEEDGSFP
LADKLLEVADYYGFDGWFINQETEGADEGTAEAMQAFLVYLQEQKPEGMH
IMWYDSMIDTGAIAWQNHLTDRNKMYLQNGSTRVADSMFLNFWWRDQRQS
NELAQALGRSPYDLYAGVDVEARGTSTPVQWEGLFPEGEKAHTSLGLYRP
DWAFQSSETMEAFYEKELQFWVGSTGNPAETDGQSNWPGMAHWFPAKSTA
TSVPFVTHFNTGSGAQFSAEGKTVSEQEWNNRSLQDVLPTWRWIQHGGDL
EATFSWEEAFEGGSSLQWHGSLAEGEHAQIELYQTELPISEGTSLTWTFK
SEHDNDLNVGFRLDGDFRYVEGEQRESINGWTQWTLPLDAFAGQTITGLA
FAAEGNETGLAEFYTGQLAVGEKPAAPNVNVRQYDPDPSGIQLVWENVHH
YRVYKETKHGKELIGTSAGDRIYIEGLVVRLHIEALSETFVPSDARMID
Ligand information
Ligand IDMAN
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5+,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-PQMKYFCFSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@@H](O)[C@@H](O)[C@@H]1O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O)O)O)O)O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-mannopyranose;
alpha-D-mannose;
D-mannose;
mannose
ChEMBLCHEMBL365590
DrugBank
ZINCZINC000003860903
PDB chain3fhq Chain E Residue 3 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3fhq Structural basis and catalytic mechanism for the dual functional endo-beta-N-acetylglucosaminidase A
Resolution2.452 Å
Binding residue
(original residue number in PDB)		G95 S96 F125 Y131
Binding residue
(residue number reindexed from 1)		G94 S95 F124 Y130
Annotation score1
Enzymatic activity
Enzyme Commision number 3.2.1.96: mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase.
Gene Ontology
Molecular Function
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0033925 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity
GO:0046872 metal ion binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006517 protein deglycosylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3fhq, PDBe:3fhq, PDBj:3fhq
PDBsum3fhq
PubMed19252736
UniProtQ9ZB22

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