Structure of PDB 3dh4 Chain B Binding Site BS02

Receptor Information

>3dh4 Chain B (length=512) Species: 670 (Vibrio parahaemolyticus)

AAAAAAAAAAAAAAAAAAGKSLPWWAVGASLIAANISAEQFIGMSGSGYS
IGLAIASYEWMSAITLIIVGKYFLPIFIEKGIYTIPEFVEKRFNKKLKTI
LAVFWISLYIFVNLTSVLYLGGLALETILGIPLMYSILGLALFALVYSIV
VWTDVIQVFFLVLGGFMTTYMAVSFIGGTDGWFAGVSKMVDAAPGHFEMI
LDQSNPQYMNLPGIAVLIGGLWVANLYYWGFNQYIIQRTLAAKSVSEAQK
GIVFAAFLKLIVPFLVVLPGIAAYVITSDPQLMASLGDIAATNLPSAANA
DKAYPWLTQFLPVGVKGVVFAALAAAIVSSLASMLNSTATIFTMDIYKEY
ISPDSGDHKLVNVGRTAAVVALIIACLIAPMLGGIGQAFQYIQEYTGLVS
PGILAVFLLGLFWKKTTSKGAIIGVVASIPFALFLKFMPLSMPFMDQMLY
TLLFTMVVIAFTSLSTSINDDDPKGISVTSSMFVTDRSFNIAAYGIMIVL
AVLYTLFWVLYK

Ligand information

• Ligand ID: NA
• InChI: InChI=1S/Na/q+1
• InChIKey: FKNQFGJONOIPTF-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [Na+]
• Formula: Na
• Name: SODIUM ION
• DrugBank: DB14516
• PDB chain: 3dh4 Chain B Residue 801

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3dh4 The crystal structure of a sodium galactose transporter reveals mechanistic insights into Na+/sugar symport.
• Resolution: 2.7 Å
• Binding residue (original residue number in PDB): I65 A361 S364
• Binding residue (residue number reindexed from 1): I36 A326 S329
• Annotation score: 5

Gene Ontology

Molecular Function

• GO:0005412 D-glucose:sodium symporter activity
• GO:0015293 symporter activity
• GO:0022857 transmembrane transporter activity

Biological Process

• GO:0006814 sodium ion transport
• GO:0055085 transmembrane transport
• GO:1904659 D-glucose transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:3dh4, PDBe:3dh4, PDBj:3dh4
• PDBsum: 3dh4
• PubMed: 18599740
• UniProt: P96169|SGLT_VIBPH Sodium/glucose cotransporter (Gene Name=sglT)