Structure of PDB 3ccr Chain B Binding Site BS02

Receptor Information

>3ccr Chain B (length=337) Species: 2238 (Haloarcula marismortui) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

PQPSRPRKGSLGFGPRKRSTSETPRFNSWPSDDGQPGVQGFAGYKAGMTH
VVLVNDEPNSPREGMEETVPVTVIETPPMRAVALRAYEDTPYGQRPLTEV
WTDEFHSELDRTLDVPEDHDPDAAEEQIRDAHEAGDLGDLRLITHTVPDA
VPSVPKKKPDVMETRVGGGSVSDRLDHALDIVEDGGEHAMNDIFRAGEYA
DVAGVTKGKGTQGPVKRWGVQKRKGKHARQGWRRRIGNLGPWNPSRVRST
VPQQGQTGYHQRTELNKRLIDIGEGDEPTVDGGFVNYGEVDGPYTLVKGS
VPGPDKRLVRFRPAVRPNDQPRLDPEVRYVSNESNQG

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

3ccr Chain B Residue 8043 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3ccr Mutations outside the anisomycin-binding site can make ribosomes drug-resistant.
Resolution	3.0 Å
Binding residue (original residue number in PDB)	N335 Q336 G337
Binding residue (residue number reindexed from 1)	N335 Q336 G337
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome
GO:0019843	rRNA binding

	Biological Process
GO:0006412	translation

	Cellular Component
GO:0005840	ribosome
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Biological Process

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Cellular Component

External links

PDB	RCSB:3ccr, PDBe:3ccr, PDBj:3ccr
PDBsum	3ccr
PubMed	18455733
UniProt	P20279\|RL3_HALMA Large ribosomal subunit protein uL3 (Gene Name=rpl3)

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