Structure of PDB 3bv9 Chain B Binding Site BS02

Receptor Information
>3bv9 Chain B (length=259) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYEANIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFGE
Ligand information
Receptor-Ligand Complex Structure
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PDB3bv9 Thrombostatin FM compounds: direct thrombin inhibitors - mechanism of action in vitro and in vivo.
Resolution1.8 Å
Binding residue
(original residue number in PDB)		Y60A W60D D189 A190 C191 E192 W215 G216 G219
Binding residue
(residue number reindexed from 1)		Y47 W50 D199 A200 C201 E202 W227 G228 G230
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E202 G203 D204 S205 G206
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:3bv9, PDBe:3bv9, PDBj:3bv9
PDBsum3bv9
PubMed18315550
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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