Structure of PDB 3b23 Chain B Binding Site BS02

Receptor Information
>3b23 Chain B (length=259) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPW
DKNFTENDLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDI
ALMKLKKPVAFSDYIHPVCLPDRETAASLLQAGYKGRVTGWGNLKETWTA
NVGKGQPSVLQVVNLPIVERPVCKDSTRIRITDNMFCAGYKPDEGKRGDA
CEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKYGFYTHVFRLKKWI
QKVIDQFGE
Ligand information
>3b23 Chain C (length=17) Species: 34610 (Amblyomma variegatum) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
HKTAPPFDFEAIPEEYL
Receptor-Ligand Complex Structure
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PDB3b23 Crystal structure of thrombin in complex with s-variegin: insights of a novel mechanism of inhibition and design of tunable thrombin inhibitors
Resolution2.4 Å
Binding residue
(original residue number in PDB)		F34 E39 L40 L41 K60F R67 R73 T74 R75 Y76 R77A Q151 E192
Binding residue
(residue number reindexed from 1)		F19 E25 L26 L27 K52 R62 R68 T69 R70 Y71 R73 Q156 E202
Enzymatic activity
Catalytic site (original residue number in PDB) H57 D102 E192 G193 D194 S195 G196
Catalytic site (residue number reindexed from 1) H43 D99 E202 G203 D204 S205 G206
Enzyme Commision number 3.4.21.5: thrombin.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0005509 calcium ion binding
Biological Process
GO:0006508 proteolysis
GO:0007596 blood coagulation

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Molecular Function
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Biological Process
External links
PDB RCSB:3b23, PDBe:3b23, PDBj:3b23
PDBsum3b23
PubMed22053189
UniProtP00734|THRB_HUMAN Prothrombin (Gene Name=F2)

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