Structure of PDB 3avn Chain B Binding Site BS02

Receptor Information

>3avn Chain B (length=149) Species: 11698 (Human immunodeficiency virus type 1 (NEW YORK-5 ISOLATE))

SPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAG
RWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEDGIPYNPQSQGVIESMNK
ELKKIIGQVRDQAEHLKTAVQMAVFIHNHKRKGYSAGERIVDIIATDIQ

Ligand information

>3avn Chain H (length=8) Species: 9606 (Homo sapiens)

SHKIDNLD

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3avn Crystal structures of novel allosteric peptide inhibitors of HIV integrase identify new interactions at the LEDGF binding site.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): Q95 T124
• Binding residue (residue number reindexed from 1): Q39 T68

Enzymatic activity

• Enzyme Commision number: 2.7.7.-
  2.7.7.49: RNA-directed DNA polymerase.
  2.7.7.7: DNA-directed DNA polymerase.
  3.1.-.-
  3.1.13.2: exoribonuclease H.
  3.1.26.13: retroviral ribonuclease H.
  3.4.23.16: HIV-1 retropepsin.

Gene Ontology

Molecular Function

• GO:0003676 nucleic acid binding

Biological Process

• GO:0015074 DNA integration

External links

• PDB: RCSB:3avn, PDBe:3avn, PDBj:3avn
• PDBsum: 3avn
• PubMed: 21850718
• UniProt: P12497|POL_HV1N5 Gag-Pol polyprotein (Gene Name=gag-pol)