Structure of PDB 3ap2 Chain B Binding Site BS02

Receptor Information

>3ap2 Chain B (length=297) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LVMVVEYRYGKAMPLIFVGGVPRSGTTLMRAMLDAHPEVRCGEETRIIPR
VLAMRQAWSKSGREKLRLDEAGVTDEVLDAAMQAFILEVIAKHGEPARVL
CNKDPFTLKSSVYLSRLFPNSKFLLMVRDGRASVHSMITRKVTIAGFDLS
SYRDCLTKWNKAIEVMYAQCMEVGKEKCLPVYYEQLVLHPRRSLKLILDF
LGIAWSDAVLHHEDLIGKPGGVSLSKIERSTDQVIKPVNLEALSKWTGHI
PGDVVRDMAQIAPMLAQLGYDPYANPPNYGNPDPFVINNTQRVLKGD

Ligand information

>3ap2 Chain T (length=9) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

EDFEDYEFD

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3ap2 Crystal structure of human tyrosylprotein sulfotransferase-2: Insights into substrate-binding and catalysis of post-translational protein tyrosine sulfation
Resolution	2.4 Å
Binding residue (original residue number in PDB)	P77 E99 R101 P104 R105 L107 Q111 P160 F161 K164 V197 T198 I199
Binding residue (residue number reindexed from 1)	P22 E44 R46 P49 R50 L52 Q56 P105 F106 K109 V142 T143 I144

Enzymatic activity

Enzyme Commision number

2.8.2.20: protein-tyrosine sulfotransferase.

Gene Ontology

	Molecular Function
GO:0008476	protein-tyrosine sulfotransferase activity

	Biological Process
GO:0006478	peptidyl-tyrosine sulfation

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Molecular Function

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Biological Process

External links

PDB	RCSB:3ap2, PDBe:3ap2, PDBj:3ap2
PDBsum	3ap2
PubMed
UniProt	O60704\|TPST2_HUMAN Protein-tyrosine sulfotransferase 2 (Gene Name=TPST2)

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