Structure of PDB 3a9z Chain B Binding Site BS02

Receptor Information
>3a9z Chain B (length=399) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RKVYMDYNATTPLEPEVIQAVTEAMKEAWGNPSSSYVAGRKAKDIINTAR
ASLAKMIGGKPQDIIFTSGGTESNNLVIHSTVRCFHEQTRPHFITCTVEH
DSIRLPLEHLVEDQVAEVTFVPVSKVNGQVEVEDILAAVRPTTCLVTIML
ANNETGVIMPISEISRRIKALNQIRAASGLPRVLVHTDAAQALGKRRVDV
EDLGVDFLTIVGHKFYGPRIGALYVRGVGKLTPLYPMLFGGGQERNFRPG
TENTPMIAGLGKAADLVSENCETYEAHMRDIRDYLEERLEAEFGKRIHLN
SRFPGVERLPNTCNFSIQGSQLRGYMVLAQCQTLLASVGASCHSDHEDRP
SPVLLSCGIPVDVARNAVRLSVGRSTTRAEVDLIVQDLKQAVNQLEGPV
Ligand information
Ligand IDSLP
InChIInChI=1S/C3H6O2Se/c4-3(5)1-2-6/h6H,1-2H2,(H,4,5)
InChIKeyDGRAMMLRUJGIJS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.0C(C[SeH])C(=O)O
CACTVS 3.352OC(=O)CC[SeH]
FormulaC3 H6 O2 Se
Name3-selanylpropanoic acid
ChEMBL
DrugBank
ZINC
PDB chain3a9z Chain B Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3a9z Reaction mechanism and molecular basis for selenium/sulfur discrimination of selenocysteine lyase.
Resolution1.55 Å
Binding residue
(original residue number in PDB)		A26 N186 K247 A373 S374 R402
Binding residue
(residue number reindexed from 1)		A9 N153 K214 A340 S341 R369
Annotation score1
Enzymatic activity
Enzyme Commision number 4.4.1.16: selenocysteine lyase.
Gene Ontology
Molecular Function
GO:0009000 selenocysteine lyase activity
GO:0016597 amino acid binding
GO:0016740 transferase activity
GO:0016829 lyase activity
GO:0042803 protein homodimerization activity
GO:0070279 vitamin B6 binding
Biological Process
GO:0001887 selenium compound metabolic process
GO:0006629 lipid metabolic process
GO:0016261 selenocysteine catabolic process
GO:0032868 response to insulin
GO:1900408 negative regulation of cellular response to oxidative stress
Cellular Component
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:1902494 catalytic complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3a9z, PDBe:3a9z, PDBj:3a9z
PDBsum3a9z
PubMed20164179
UniProtQ68FT9|SCLY_RAT Selenocysteine lyase (Gene Name=Scly)

[Back to BioLiP]