Structure of PDB 2zp7 Chain B Binding Site BS02

Receptor Information
>2zp7 Chain B (length=391) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SWSEAFGKGAGRIQASTIRELLKLTQRPGILSFAGGLPAPELFPKEEAAE
AAARILREKGEVALQYSPTEGYAPLRAFVAEWIGVRPEEVLITTGSQQAL
DLVGKVFLDEGSPVLLEAPSYMGAIQAFRLQGPRFLTVPAGEEGPDLDAL
EEVLKRERPRFLYLIPSFQNPTGGLTPLPARKRLLQMVMERGLVVVEDDA
YRELYFGEARLPSLFELAREAGYPGVIYLGSFSKVLSPGLRVAFAVAHPE
ALQKLVQAKQGADLHTPMLNQMLVHELLKEGFSERLERVRRVYREKAQAM
LHALDREVPKEVRYTRPKGGMFVWMELPKGLSAEGLFRRALEENVAFVPG
GPFFANGGGENTLRLSYATLDREGIAEGVRRLGRALKGLLA
Ligand information
Ligand IDLEU
InChIInChI=1S/C6H13NO2/c1-4(2)3-5(7)6(8)9/h4-5H,3,7H2,1-2H3,(H,8,9)/t5-/m0/s1
InChIKeyROHFNLRQFUQHCH-YFKPBYRVSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0CC(C)C[C@@H](C(=O)O)N
CACTVS 3.341CC(C)C[C@H](N)C(O)=O
OpenEye OEToolkits 1.5.0CC(C)CC(C(=O)O)N
ACDLabs 10.04O=C(O)C(N)CC(C)C
CACTVS 3.341CC(C)C[CH](N)C(O)=O
FormulaC6 H13 N O2
NameLEUCINE
ChEMBLCHEMBL291962
DrugBankDB00149
ZINCZINC000003645145
PDB chain2zp7 Chain B Residue 700 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2zp7 Mechanism for multiple-substrates recognition of alpha-aminoadipate aminotransferase from Thermus thermophilus
Resolution2.26 Å
Binding residue
(original residue number in PDB)		L26 G39 G40 K238 R368
Binding residue
(residue number reindexed from 1)		L22 G35 G36 K234 R364
Annotation score2
Enzymatic activity
Enzyme Commision number 2.6.1.39: 2-aminoadipate transaminase.
Gene Ontology
Molecular Function
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0047536 2-aminoadipate transaminase activity
Biological Process
GO:0009058 biosynthetic process
GO:0019878 lysine biosynthetic process via aminoadipic acid
GO:1901605 alpha-amino acid metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2zp7, PDBe:2zp7, PDBj:2zp7
PDBsum2zp7
PubMed18831049
UniProtQ72LL6|LYSN_THET2 2-aminoadipate transaminase (Gene Name=lysN)

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